Relationship between primary structure and activity in exorphins and endogenous opioid peptides
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Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Bakalkin Gya1, H U Demuth, F Nyberg
1Department of Drug Dependence Research, Karolinska Institute, Stockholm, Sweden.
Abstract:
We have found a correlation between the certain characteristics of primary structure and biologic activity in exorphins and endogenous opioid peptide family. The characteristics of primary structure are the content of certain segment pairs as well as the density of their arrangement in a peptide. These segment pairs represent basic elements of the regulatory peptide primary structure pattern, which was found recently [Dokl. Akad. Nauk USSR 289 (1986) 721-724; Int. J. Peptide Prot. Res. 38 (1991) 505-510].
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