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Updated: Aug 23, 2026

Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
Published on: July 8, 2025
New flavin and deazaflavin oligonucleotide conjugates for the amperometric detection of DNA hybridization
Serge Cosnier1, Chantal Gondran, Cécile Dueymes
1Laboratoire d'Electrochimie Organique et de Photochimie Rédox UMR 5630 CNRS Institut de Chimie Moléculaire de Grenoble FR CNRS 2607, Université Joseph Fourier, BP 53, 38041 Grenoble 9, France. serge.cosnier@ujf-grenoble.fr
Abstract:
The functionalization of an oligonucleotide by flavin and deazaflavin derivatives allowed an amperometric determination of the hybridization process through the disappearance of the electroactivity of the free oligonucleotide and the appearance of a new electrochemical signal characteristic of the resulting duplex.
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