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Macrophage behavior on surface-modified polyurethanes.

Jacqueline A Jones1, Mahrokh Dadsetan, Terry O Collier

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.

Journal of Biomaterials Science. Polymer Edition
|July 22, 2004
PubMed
Summary
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Silicone modification of polyurethanes altered macrophage behavior, promoting foreign body giant cell (FBGC) formation or apoptosis. Other surface modifications did not impact macrophage adhesion or activity.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Immunology

Background:

  • Polyurethanes (PUs) are susceptible to degradation by molecules released from adherent macrophages and foreign body giant cells (FBGCs).
  • Surface modification of PUs using surface modifying endgroups (SMEs) or silicone incorporation may improve long-term biostability by altering cellular responses.

Purpose of the Study:

  • To investigate the in vitro effects of fluorocarbon SMEs, polyethylene oxide (PEO) SMEs, and poly(dimethylsiloxane) (PDMS) silicone modification on macrophage adhesion, fusion, and apoptosis on polyurethanes.

Main Methods:

  • Polyurethanes were modified with fluorocarbon SMEs, PEO SMEs, or PDMS co-soft segment and SMEs.
  • In vitro assays assessed macrophage adhesion, fusion (including FBGC formation), and apoptosis on modified and unmodified polyurethanes, with and without IL-4 stimulation.

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Main Results:

  • Fluorocarbon and PEO SME modifications showed no significant effect on macrophage adhesion, fusion, or apoptosis.
  • Silicone modification exhibited varied effects; macrophages adhered similarly to modified and unmodified surfaces.
  • In the absence of IL-4, macrophage fusion was comparable, but apoptosis was promoted on silicone-modified PUs.
  • In the presence of IL-4, silicone modification significantly increased macrophage fusion to form FBGCs.

Conclusions:

  • Fluorocarbon and PEO SME modifications do not influence macrophage interactions relevant to polyurethane biostability.
  • Silicone modification can modulate macrophage fate, promoting either FBGC formation or apoptosis.
  • Silicone modification offers a strategy to control cellular responses for enhanced long-term polyurethane biostability.