Related Experiment Video
Updated: Aug 23, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
Difficult extubation: calming the sympathetic storm
A Kulkarni1, G Price, M Saxena
1Intensive Care Unit, The St. George Hospital, Sydney, New South Wales.
Abstract:
Tracheal extubation can evoke an equally strong haemodyamic stress response as tracheal intubation. We present a patient with myocardial infarction who repeatedly failed tracheal extubation. He developed acute pulmonary oedema following each attempt at tracheal extubation due to sympathetic overactivity. A change of approach with extubation under propofol sedation followed by continued sympatholysis with dexmedetomidine infusion allowed successful extubation.
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