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Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco
Juan C Hernández1, Francisco León, José Quintana
1Instituto de Productos Naturales y Agrobiología-CSIC, Instituto Universitario de Bio-Orgánica Antonio González, La Laguna, Tenerife, Spain.
Abstract:
This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.
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