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The NAADP receptor: commentary on Billington et al
A Galione1, J Parrington, J Dowden
1Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT. galione@pharm.ox.ac.uk
British Journal of Pharmacology
|July 22, 2004
Summary
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a calcium messenger found in sea urchin eggs and mammalian cells. Billington et al. explored new molecules to modulate NAADP receptors, aiding research into its cell signaling role.
Area of Science:
- Cellular signaling
- Molecular biology
- Biochemistry
Background:
- Nicotinic acid adenine dinucleotide phosphate (NAADP) is a recently identified calcium-mobilizing messenger.
- Its function has been observed in sea urchin eggs and various mammalian cell types.
- NAADP-sensitive calcium release channels in sea urchin eggs are distinct from IP3 and ryanodine receptors and located in acidic compartments.
Discussion:
- This study explores the pharmacology of the putative NAADP receptor using novel molecules.
- The research aims to identify compounds that can modulate NAADP receptor activity.
- Understanding these modulators is crucial for dissecting the signaling pathways involving NAADP.
Key Insights:
- Billington et al. have expanded the known pharmacology of the NAADP receptor.
- The development of selective NAADP receptor modulators is a key objective.
- This research provides tools to investigate NAADP's role in cellular processes.
Outlook:
- Further development of selective NAADP receptor modulators is anticipated.
- These modulators will be instrumental in elucidating the precise functions of NAADP in diverse cell signaling events.
- This line of research holds potential for understanding and treating diseases linked to calcium signaling dysregulation.
