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Related Experiment Videos

Erasing restylane.

Charles N S Soparkar1, James R Patrinely, Jamie Tschen

  • 1Plastic Eye Surgery Associates, PLLC, 6655 Travis Street, Houston, TX 77030, U.S.A. pesa_2004@sbcglobal.net

Ophthalmic Plastic and Reconstructive Surgery
|July 22, 2004
PubMed
Summary
This summary is machine-generated.

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Restylane, a cross-linked hyaluronic acid filler, caused an undesirable cosmetic outcome lasting over five years. Hyaluronidase injection effectively and rapidly reversed the Restylane filler effects.

Area of Science:

  • Dermatology
  • Cosmetic Surgery
  • Aesthetic Medicine

Background:

  • Hyaluronic acid fillers are widely used for cosmetic facial rejuvenation.
  • Cross-linked hyaluronic acid, such as Restylane, offers extended duration but can pose challenges for reversal.
  • Periorbital rhytids are common aging concerns addressed by minimally invasive aesthetic procedures.

Observation:

  • A 65-year-old patient experienced an undesirable aesthetic result following Restylane injections for periorbital rhytids.
  • The cosmetic filler effect persisted for an unusually long duration, exceeding five years.
  • Direct injection of hyaluronidase was administered to address the persistent filler effect.

Findings:

  • Hyaluronidase effectively and rapidly resolved the persistent Restylane filler effect.

Related Experiment Videos

  • The enzymatic degradation by hyaluronidase provided a successful reversal of the undesired cosmetic outcome.
  • This case highlights the efficacy of hyaluronidase in managing long-lasting hyaluronic acid filler complications.

    • Implications:

    • Hyaluronidase serves as a valuable antidote for managing adverse or persistent effects of hyaluronic acid fillers.
    • Clinicians should be aware of the potential for long duration of action with certain hyaluronic acid fillers.
    • Prompt and effective management strategies are crucial for patient satisfaction in aesthetic procedures.