Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current situation of clinical trial registration in acupuncture anesthesia: A scoping review.

Journal of integrative medicine·2025
Same author

Efficacy and safety of Lianhua Qingwen capsules combined with standard of care in the treatment of adult patients with mild to moderate COVID-19 (FLOSAN): protocol for a randomized, double-blind, international multicenter clinical trial.

Journal of thoracic disease·2023
Same author

Chinese guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2018 Edition).

Journal of thoracic disease·2019
Same author

Macrolide-resistant <i>Mycoplasma pneumoniae</i> prevalence and clinical aspects in adult patients with community-acquired pneumonia in China: a prospective multicenter surveillance study.

Journal of thoracic disease·2017
Same author

Diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association.

The clinical respiratory journal·2017
Same author

Therapeutic drug monitoring of vancomycin: a guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society.

The Journal of antimicrobial chemotherapy·2016
Same journal

Splenic Angiosarcoma Misdiagnosed as PrimaryMyelofibrosis: Report of Two Cases and a Literature Review.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

Anesthetic Management for Epicardial Pacemaker Implantation in An Adult Patient With Uncorrected Functional Single Ventricle:A Case Report.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

Magnetic Resonance Imaging Combined With Ultrasonography for Early Diagnosis of Complete Hydatidiform Mole With Coexisting Fetus: Report of One Case.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

Prospects for China's Pharmaceutical Industry Development During the 15th Five-Year Plan Period.

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

[Comparison of Imaging Efficacy and Patient Tolerability Between a Novel Cellulose-Based anda Conventional Starch-Based Oral Contrast Agent: A Prospective Randomized Controlled Trial].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
Same journal

[Application Value of Super-Resolution Ultrasound Imaging in the Diagnosisof American College of Radiology Thyroid Imaging Reporting and Data System Category 4 and 5 Thyroid Nodules].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

[Inspiration from diffuse panbronchiolitis].

You-ning Liu1

  • 1Department of Respiratory Disease, Chinese PLA General Hospital, Beijing 100853, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|July 23, 2004
PubMed
Summary
This summary is machine-generated.

Diffuse panbronchiolitis, a respiratory disease, shows a genetic link to race-specific antigens. Macrolide antibiotics effectively treat this condition, highlighting the importance of considering racial differences in disease.

More Related Videos

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
07:40

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Related Experiment Videos

Last Updated: Jun 24, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
07:40

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Area of Science:

  • Pulmonology
  • Genetics
  • Pharmacology

Background:

  • Diffuse panbronchiolitis is an emerging respiratory disease identified in Japan.
  • A significant association exists between race-dependent antigens and diffuse panbronchiolitis, suggesting a genetic predisposition.
  • 14- and 15-member ring macrolides demonstrate therapeutic efficacy.

Discussion:

  • The discovery of diffuse panbronchiolitis underscores the need to acknowledge racial variations in disease presentation and susceptibility.
  • Macrolide therapy offers a significant treatment avenue for this specific respiratory condition.
  • Clinical practice should remain vigilant for unexpected phenomena and consider ethnic factors in diagnosis and treatment.

Key Insights:

  • Genetic predisposition plays a role in diffuse panbronchiolitis, linked to race-specific antigens.
  • Macrolide antibiotics are effective treatments for diffuse panbronchiolitis.
  • Racial differences are crucial considerations in understanding and managing certain diseases.

Outlook:

  • Further research into the genetic underpinnings of diffuse panbronchiolitis across diverse populations is warranted.
  • Optimizing macrolide therapy based on racial and genetic profiles may improve patient outcomes.
  • Increased clinical awareness of ethnic variations in respiratory diseases is essential for advancing patient care.