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Tear evaporation from the ocular surface.

K Tsubota1, M Yamada

  • 1Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.

Investigative Ophthalmology & Visual Science
|September 1, 1992
PubMed
Summary
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A new method accurately measures tear evaporation, revealing lower rates in dry eye patients. Treatments like collagen implants and certain eye drops can temporarily increase tear evaporation.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Physiology

Background:

  • Tear evaporation is a key factor in ocular surface health.
  • Accurate measurement of tear evaporation is crucial for diagnosing and managing dry eye disease.
  • Existing methods may be complex or time-consuming.

Purpose of the Study:

  • To develop and validate a simple, reliable method for measuring tear evaporation rate.
  • To assess tear evaporation in normal subjects and patients with dry eye symptoms.
  • To evaluate the impact of interventions like lacrimal implants and eye drops on tear evaporation.

Main Methods:

  • A novel chamber-based sensor system was used to measure humidity changes.
  • Tear evaporation rate at 40% ambient humidity (TEROS 40) was calculated based on humidity differences between open and closed eye conditions.

Related Experiment Videos

  • TEROS 40 was measured in healthy individuals and dry eye patients, with and without interventions.

    • Main Results:

    • Normal subjects had an average TEROS 40 of 15.6 x 10(-7) g/sec.
    • Dry eye patients exhibited significantly lower TEROS 40 (9.5 x 10(-7) g/sec).
    • Lacrimal collagen implants and viscous eye drops (sodium hyaluronic acid) increased TEROS 40, while standard artificial tears had a shorter-lasting effect.

    Conclusions:

    • The developed method provides a quick and reliable assessment of ocular surface tear evaporation.
    • This technique can aid in the evaluation of tear dynamics and the subclassification of dry eye disease.
    • Findings highlight differences in tear evaporation between healthy and dry eye states and the variable effects of treatments.