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[Diagnostic problems in local recurrence after breast saving treatment].
Helvetica Chirurgica Acta
|May 1, 1992
Summary
Breast conserving therapy for early-stage breast cancer showed an 8% local failure rate. Mammography and biopsy accurately identified post-actinic induration in 82% of cases, aiding in local failure assessment.
Area of Science:
- Oncology
- Surgical Oncology
- Radiology
Context:
- Prospective study of 353 early-stage breast cancer patients (pTis-pT2, pN0-1, cM0).
- Treatment involved breast conserving therapy (BCT) at University Hospital Basel and Women's Clinic Rheinfelden.
- Median follow-up of 67 months with low loss to follow-up (4%).
Purpose:
- To evaluate the efficacy and outcomes of BCT in early-stage breast cancer.
- To assess the rate of local failure after BCT.
- To determine the diagnostic accuracy of clinical examination, mammography, and biopsy in evaluating post-actinic induration.
Summary:
- Total tumor excision was achieved in 79% of cases; positive resection margins occurred in 19%.
- The local failure rate was 8%, with a median time to failure of 53 months.
- In patients with post-actinic induration, mammography (82% accuracy) and biopsy were more reliable than clinical assessment (59% accuracy) in identifying local failure.
Impact:
- BCT demonstrates a low local failure rate in selected early-stage breast cancer patients.
- Accurate assessment of post-actinic induration is crucial for timely intervention and management of local recurrence.
- Findings support the role of mammography and biopsy in differentiating benign post-treatment changes from local tumor recurrence.