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Related Experiment Videos

Breast conservation: long-term Australian data.

J Boyages1, C Bosch, A O Langlands

  • 1Division of Radiation Oncology, Westmead Hospital, NSW, Australia.

International Journal of Radiation Oncology, Biology, Physics
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Conservative surgery and radiation therapy offer low recurrence rates for early breast cancer, regardless of surgical extent. Combining axillary surgery and radiation increases arm edema risk.

Area of Science:

  • Oncology
  • Radiotherapy
  • Surgical Oncology

Background:

  • Limited long-term data exists for conservative surgery and radiation therapy in early breast cancer management in Australia.
  • This study reviews the experience of 131 early-stage breast cancer patients treated between 1979 and 1985.

Purpose of the Study:

  • To evaluate the long-term outcomes and complications of conservative surgery followed by radiation therapy for early breast cancer.
  • To determine if the extent of surgical resection impacts recurrence rates.

Main Methods:

  • Retrospective review of 131 patients with Stage I or II breast cancer.
  • Treatment involved conservative surgery (local excision to quadrantectomy) with or without axillary dissection, followed by whole breast irradiation (6 MeV photons) and optional iridium-192 boost.

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  • Median follow-up was 83 months.

    • Main Results:

    • The 5-year actuarial breast recurrence rate was 4.5%.
    • Recurrence rates were independent of the extent of surgical resection.
    • The 5-year freedom from distant relapse was 80%.
    • Complications included rib fracture (5%), pneumonitis (4%), and fat necrosis (4.5%).
    • Combined axillary surgery and radiation therapy significantly increased moderate to severe arm edema (29%) compared to either modality alone (8% and 6%).

    Conclusions:

    • Conservative surgery combined with radiation therapy provides durable, low rates of breast cancer recurrence for early-stage disease.
    • Surgical extent does not influence local recurrence risk.
    • Careful selection of axillary treatment is crucial to minimize lymphedema complications, avoiding combined surgery and radiation.