Protein and peptide parenteral controlled delivery

Area of Science:

• Biotechnology
• Pharmaceutical Sciences
• Materials Science

Background:

• Protein and peptide drugs exhibit limited stability during formulation, storage, and release.
• Traditional administration routes for these biopolymers are invasive (intramuscular, subcutaneous).
• Non-invasive delivery methods (oral, intranasal, transdermal, transmucosal) are under development but not yet dominant.

Purpose of the Study:

• To review recent advancements in injectable, polymeric controlled-release formulations for protein and peptide delivery.
• To highlight the role of hydrogels and particulate systems in this field.

Main Methods:

• Literature review of recent developments in controlled-release drug delivery systems.
• Focus on polymeric formulations, specifically hydrogels and particulate systems.
• Analysis of stability, administration routes, and release mechanisms for protein and peptide drugs.

Main Results:

• Injectable polymeric formulations offer promising controlled-release strategies.
• Hydrogels and particulate systems are key technologies for enhancing stability and controlled release.
• Despite progress in non-invasive methods, invasive delivery remains prevalent.

Conclusions:

• Injectable polymeric controlled-release systems, particularly hydrogels and particulate systems, are crucial for overcoming protein and peptide delivery challenges.
• Further research into these formulations can improve therapeutic efficacy and patient compliance.
• These advanced systems represent a significant step towards more effective protein and peptide drug administration.