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Extramedullary hematopoiesis in a pyogenic granuloma: a case report and review
Suzana M Vega Harring1, Madinyet Niyaz, Shinya Okada
1Department of Pathology, Tokyo Medical University, Nishi-Shinjuku, Shinjuku-Ku, Tokyo 160-8402, Japan.
Background:
Extramedullary hematopoiesis in the adult life is usually associated with hematological disorders. It can often occur in several organs under certain pathological conditions, including the spleen, liver, and skin, which are normal sites during the embryogenesis, the skin being very uncommon.
Case Report:
A case of extramedullary hematopoiesis in a granuloma pyogenicum at the anterior aspect of the right thigh of a 31-year-old Japanese man is reported.
Results:
Histologic examination revealed an ulcerated polypoid lesion composed of numerous newly formed capillaries and a myxoid edematous stroma. In addition, three islands of hematopoietic precursors were found.
Conclusions:
This is, to our knowledge, the second case of extramedullary hematopoiesis in a granuloma pyogenicum. We believe that vascular lesions have potential to generate hematopoietic precursor cells; however, hematopoiesis will only occur in a setting of adequate microenvironment, as it occurs in the bone marrow.
