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Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine
Magdi El-Sayed1, Young H Choi, M Frédérich
1Department of Pharmacognosy, Section of Metabolomics, Institute of Biology Leiden, Leiden University, The Netherlands.
Biotechnology Letters
|July 23, 2004
Abstract:
Feeding stemmadenine to Catharanthus roseus cell suspension culture resulted in the accumulation of catharanthine, tabersonine and condylocarpine. Condylocarpine is not an intermediate in the pathway to catharanthine or tabersonine when it is fed to the cultures. The results support the hypothesis that stemmadenine is an intermediate in the pathway to catharanthine and tabersonine.
