[Experience of repairing alveolar bone defects by collagen membrane and hydroxyapatite and its long-term result]
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Updated: Aug 23, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
Published on: July 14, 2023
Zhong-Suo Huang1, Xiao-Hong Ding
1Department of Periodontics, The Stomatological Hospital of Hefei, Hefei 230001, Anhui Province, China. HZhS3110@mail.hf.ah.cn
Purpose:
To observe the clinical effect of using the domestic BME-10X medical collagen membrane and hydroxyapatite (HA) in guide tissue regeneration of the bone defects caused by periodontitis and periapical cyst.
Methods:
18 cases with 9 points in 9 teeth with II degree furation involvement, 16 points in 11 teeth with 2 or 3 bone bottom pockets and 6 cases with periapical cyst were chosen in our study. The defect region of alveolar bone was stuffed with HA and covered with collagen membrane. The pathological changes after over one year were observed and recorded.
Results:
The pathological changes of alveolar bone defects were significant in 7 cases with furcation involvements (77.8%),12 cases with bone bottom pockets (75%),and 6 cases of periapical cyst (100%).
Conclusion:
The combination of collagen membrane and HA can be applied in repairing the alveolar bone defects resulting form periodontitis and periapical cysts.

