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Published on: May 29, 2020
Autoimmune polyglandular syndrome Type 2: the tip of an iceberg?
C Betterle1, F Lazzarotto, F Presotto
1Unit of Endocrinology, Department of Medical and Surgical Sciences, University of Padua, Italy. corrado.betterle@unipd.it
Abstract:
Autoimmune polyglandular syndromes (APS) are conditions characterized by the association of two or more organ-specific disorders. Type 2 APS is defined by the occurrence of Addison's disease with thyroid autoimmune disease and/or Type 1 diabetes mellitus. Clinically overt disorders are considered only the tip of the autoimmune iceberg, since latent forms are much more frequent. Historical, clinical, genetic, and immunological aspects of Type 2 APS are reviewed. Furthermore, data on 146 personal cases of Type 2 APS are also reported.
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