Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA damage and aging.

Zarir E Karanjawala1, Michael R Lieber

  • 1Department of Pathology, USC Norris Comprehensive Center, Los Angeles, CA 90033, USA.

Mechanisms of Ageing and Development
|July 27, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complex Indel Detection: A Simulation-Based Framework and Parsing with FreeBayes.

bioRxiv : the preprint server for biology·2026
Same author

Mutation count and mutation profile analyses of single-nucleotide variants in single human colon crypts.

bioRxiv : the preprint server for biology·2026
Same author

RAG-mediated structural variation and its impact on relapse risk in acute lymphoblastic leukemia.

medRxiv : the preprint server for health sciences·2026
Same author

Fine Structural Features of Complex InDels and NHEJ Repair at Naturally Occurring Damage Sites in Normal Human Colon Crypts.

bioRxiv : the preprint server for biology·2026
Same author

Author Correction: Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia.

Nature immunology·2025
Same author

High-depth Whole Genome Sequencing of Single Human Colon Crypts Uncovers New View on Crypt Clonality.

bioRxiv : the preprint server for biology·2025
Same journal

Circulating Elastin Fragments Drive Systemic Aging: Where Do Pro-Aging Elastin Fragments Come From?- A Mini-Review.

Mechanisms of ageing and development·2026
Same journal

Human sex-specific hormone effects on cerebrovascular health in males and females.

Mechanisms of ageing and development·2026
Same journal

HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan.

Mechanisms of ageing and development·2026
Same journal

PCSK9 promotes aging-related cardiac calcification by inducing osteogenic differentiation of cardiac fibroblasts.

Mechanisms of ageing and development·2026
Same journal

Distinct post-infectious TLR2 immune remodeling in COVID-19-recovered centenarians.

Mechanisms of ageing and development·2026
Same journal

Senescence-associated tertiary lymphoid structures in Sjögren's disease model nishiura mice.

Mechanisms of ageing and development·2026
See all related articles

Oxidative damage to nuclear DNA is a key aging factor in animals. A specific DNA repair pathway, nonhomologous DNA end joining (NHEJ), may influence lifespan by affecting genome stability.

Area of Science:

  • Genetics
  • Molecular Biology
  • Aging Research

Background:

  • Oxidative damage to nuclear DNA is hypothesized as a major aging component in metazoans.
  • Premature aging syndromes in mammals are linked to mutations in nuclear proteins, including those involved in DNA metabolism and repair.

Purpose of the Study:

  • To explore the role of oxidative DNA damage and repair pathways in aging.
  • To investigate the significance of nonhomologous DNA end joining (NHEJ) in relation to organismal lifespan.

Main Methods:

  • Review of existing literature on aging, DNA damage, and repair mechanisms.
  • Analysis of the characteristics of eukaryotic DNA repair pathways, specifically nonhomologous DNA end joining (NHEJ).

Main Results:

Related Experiment Videos

  • Nonhomologous DNA end joining (NHEJ) is a primary pathway for repairing double-strand DNA breaks.
  • NHEJ can result in small deletions, failing to restore full genomic information.
  • Repetitive DNA content may influence the efficiency of NHEJ and impact organismal lifespan.

Conclusions:

  • Oxidative damage to nuclear DNA is a significant contributor to aging.
  • The efficiency of nonhomologous DNA end joining (NHEJ), potentially influenced by repetitive DNA, plays a critical role in balancing oxidative stress and determining lifespan.