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[Immunosuppressive activity of exopolysaccharide from Paecilomyces gunnii]
Jianhui Xiao1, Ning Fang, Yu Xiao
1Key Lab. of Cell Engineering of Guizhou Province, the Affiliated Hospital of Zunyi Medical College, Zunyi 563003.
Objective:
To investigate bioactivities of Paecilomyces gunnii exopolysaccharide (PGEP).
Methods:
The effects of PGEP on mice spleen lymphocytes proliferation, mice peritoneal macrophage (PMphi) phagocytosis and cytotoxin T lymphocytes (CTL) activity were studied by MTT method, neutral red colorimetry, respectively.
Results:
In vitro, mice spleen lymphocytes proliferation, mice peritoneal macrophage (PMphi) phagocytosis of neutral red and CTL activity were significant suppressed by PGEP, especially in 10 microg/ml.
Conclusion:
PGEP had the immunosuppressive activities.
