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Related Experiment Videos

Asthma and sinusitis.

R G Slavin1

  • 1Department of Internal Medicine and Microbiology, St. Louis University School of Medicine, MO 63110.

The Journal of Allergy and Clinical Immunology
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Treating sinusitis, an upper airway condition, often improves asthma symptoms in patients with both conditions. This suggests sinusitis may trigger asthma, with potential mechanisms involving inflammation and nerve reflexes.

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Area of Science:

  • Otolaryngology
  • Pulmonology
  • Immunology

Background:

  • Sinusitis and asthma frequently coexist in patients.
  • Accumulating evidence suggests a causal link where sinusitis triggers asthma.

Purpose of the Study:

  • To explore the relationship between upper and lower airway conditions, specifically sinusitis and asthma.
  • To review evidence supporting sinusitis as a trigger for asthma and its treatment implications.

Main Methods:

  • Review of existing studies in children and adults examining the link between sinusitis and asthma.
  • Analysis of potential biological mechanisms connecting the upper and lower airways.

Main Results:

  • Therapy for sinusitis (medical and/or surgical) often results in improved asthma control.

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  • Identified potential mechanisms include eosinophil activity, inflammatory mediators, and vagal reflexes.

    • Conclusions:

    • Sinusitis is a significant factor that can trigger or exacerbate asthma.
    • Further research, including prospective studies and basic science investigations, is warranted to fully elucidate the upper and lower airway connection.