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Updated: Aug 5, 2026

Operant Procedures for Assessing Behavioral Flexibility in Rats
Published on: February 15, 2015
Effect of M4-cholinoceptor blockade on haloperidol-produced catatonic syndrome in rats
S G Dagaev1, A B Kosmachev, O A Filko
1Institute of Toxicology, Russian Ministry of Health, St. Petersburg, Russia.
Abstract:
We studied the relationship between the efficiency of muscarinic receptor antagonists in preventing haloperidol-induced catatonia and their activity in tests for the interaction of ligands with various subtypes of muscarinic receptors (M1-M4) in rats. Mathematical modeling showed that affinity of the ligand for M4 receptors positively affects its ability to correct extrapyramidal disorders (catatonic syndrome) produced by haloperidol, while affinity for M2 receptors had a negative effect on this characteristic.
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