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[Total prostatectomy for stage D1 cancers].

A Ponthieu1, E Lechevalier, J Delgrande

  • 1Centre d'Urologie Castellane, Marseille.

Journal D'Urologie
|January 1, 1992
PubMed
Summary

Radical prostatectomy combined with adjuvant radiation therapy offers a curative approach for stage D1 prostatic adenocarcinoma. This multimodal treatment demonstrates significant long-term survival rates and cancer-free outcomes.

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Area of Science:

  • Urology
  • Oncology
  • Radiation Oncology

Context:

  • Stage D1 prostatic adenocarcinoma presents advanced disease with lymph node involvement.
  • Radical prostatectomy and adjuvant radiation therapy are established treatment modalities.
  • Hormonal therapy was not utilized in this patient cohort.

Purpose:

  • To evaluate the efficacy of radical prostatectomy followed by adjuvant radiation therapy in patients with stage D1 prostatic adenocarcinoma.
  • To assess long-term survival and cancer-free outcomes in this patient group.
  • To compare outcomes with existing literature on nonsurgical and surgical treatments.

Summary:

  • Nineteen patients with stage D1 prostatic adenocarcinoma underwent radical prostatectomy and adjuvant radiation therapy (aortoiliac for B, aortoiliac/pelvic for C).
  • Lymph node invasion varied, with multifocal, bilateral, or massive involvement in several cases.
  • Follow-up ranged from 1 to 17 years; 47% of patients were alive and healthy, with 26% disease-free without further treatment.

Impact:

  • The combination of surgery and radiation therapy shows promise for curative intent in advanced prostate cancer.
  • Prostate-specific antigen (PSA) monitoring is crucial for surveillance post-treatment.
  • Nonsurgical treatments are generally palliative for stage D1 tumors, highlighting the importance of adjuvant radiation post-surgery.

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