[Local recurrence of renal carcinoma after laparoscopic partial nephrectomy]
T Negre1, E Lechevalier, M André
1Service d'urologie et de transplantation rénale, CHU Conception, 147, boulevard Baille, 13385 Marseille, France. thibault@negre.fr
Summary
This case study details early recurrence of clear cell renal carcinoma (CCRC) after partial nephrectomy. Treatment with sunitinib ultimately led to a complete response in metastatic disease.
Area of Science:
- Urology
- Oncology
- Nephrology
Background:
- Laparoscopic partial nephrectomy (LPN) is a standard treatment for localized renal tumors.
- Clear cell renal carcinoma (CCRC) can recur locally or metastasize after treatment.
Observation:
- A patient with Fuhrman grade 1-2 CCRC experienced early local recurrence 6 months post-LPN.
- Further recurrence, including perirenal nodules (grade 3 CCRC), wound recurrence, and distant metastases (pulmonary, liver, adrenal), occurred over 26 months.
Findings:
- Despite multiple recurrences and metastases, the patient achieved a total response after 4 months of oral sunitinib treatment.
- This case highlights the potential for aggressive CCRC recurrence patterns even after initial nephron-sparing surgery.
Implications:
- Aggressive surveillance may be warranted for patients with initially low-grade CCRC treated with LPN.
- Sunitinib demonstrates efficacy in managing advanced or metastatic CCRC following surgical interventions.
- Further research into predicting recurrence risk and optimizing treatment strategies for CCRC is crucial.
