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Related Experiment Videos

SWISS-2DPAGE, ten years later.

Christine Hoogland1, Khaled Mostaguir, Jean-Charles Sanchez

  • 1Swiss Institute of Bioinformatics, Geneva, Switzerland. Christine.Hoogland@isb-sib.ch

Proteomics
|July 27, 2004
PubMed
Summary

The SWISS-2DPAGE database offers extensive proteomic data with over 1200 protein entries and 36 reference maps. This valuable resource is continuously updated and integrated with other databases for broad accessibility.

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Area of Science:

  • Proteomics
  • Bioinformatics
  • Database Development

Background:

  • The SWISS-2DPAGE database has been a key resource since 1993.
  • It is a collaborative effort between the Swiss Institute of Bioinformatics (SIB) and the Geneva University Hospital's Biomedical Proteomics Research Group (BPRG).
  • The database has undergone continuous development and improvement over the years.

Purpose of the Study:

  • To maintain and enhance a comprehensive two-dimensional polyacrylamide gel electrophoresis (2DPAGE) protein database.
  • To provide a high-quality, annotated resource for the proteomics community.
  • To integrate proteomic data with other relevant biological databases.

Main Methods:

  • Curating and identifying protein spots from 2DPAGE maps.

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  • Annotating protein entries with detailed information.
  • Integrating the database with other bioinformatics resources.
  • Developing and maintaining reference maps for various organisms.

    • Main Results:

    • The database currently contains approximately 4000 identified spots, representing 1200 unique protein entries.
    • It includes 36 reference maps from diverse organisms such as human, mouse, Arabidopsis thaliana, Dictyostelium discoideum, Escherichia coli, Saccharomyces cerevisiae, and Staphylococcus aureus.
    • The SWISS-2DPAGE database exhibits a high level of annotation and seamless integration with other pertinent databases.
    • The database receives approximately 1000 queries per day, indicating its significant usage and importance.

    Conclusions:

    • SWISS-2DPAGE is a well-established and continuously improving reference database in proteomics.
    • Its extensive data, high annotation level, and integration capabilities make it an indispensable tool for researchers.
    • The high daily query rate underscores its value and widespread use in the scientific community.