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Doxorubicin-poly(acrylic acid) complexes: interaction with liposomes.
M V Kitaeva1, N S Melik-Nubarov, F M Menger
1School of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119899, Leninskie Gory, Russian Federation.
Langmuir : the ACS Journal of Surfaces and Colloids
|July 28, 2004
Summary
Antitumor drug doxorubicin (DOX) forms complexes with poly(acrylic acid) (PAA), creating larger particles. These particles then interact with liposomes, forming a ternary complex useful for drug delivery applications.
Area of Science:
- Polymer chemistry
- Nanomedicine
- Drug delivery systems
Background:
- Doxorubicin (DOX) is a potent antitumor drug.
- Poly(acrylic acid) (PAA) is a versatile polymer for drug complexation.
- Developing effective drug delivery systems is crucial for cancer therapy.
Purpose of the Study:
- To investigate the complexation of doxorubicin (DOX) with poly(acrylic acid) (PAA).
- To characterize the resulting DOX-PAA complex and its interaction with liposomes.
- To explore the potential of these complexes as bioactive constructs for drug delivery.
Main Methods:
- Complexation studies in buffer solutions.
- Analysis of binding interactions (electrostatic and stacking).
- Particle size determination using dynamic light scattering.
- Investigation of ternary complex formation with egg yolk lecithin liposomes.
Main Results:
- DOX-PAA complex formation with a PAA/DOX molar ratio of 1.6.
- Complex particle sizes ranged from 600-900 nm.
- Formation of a ternary DOX/PAA/liposome complex through interaction with liposomes (80-100 nm).
Conclusions:
- Electrostatic and stacking interactions drive DOX-PAA complex formation.
- The DOX-PAA complex can be further functionalized by interacting with liposomes.
- These polymer-liposome complexes show promise for advanced bioactive constructs in cancer therapy.