A proposed nomenclature for bile acids

Area of Science:

• Biochemistry
• Organic Chemistry
• Nomenclature Systems

Background:

• Bile acids are crucial biological molecules with complex structures.
• Existing nomenclature for bile acids can be inconsistent and confusing.
• A unified system is needed for clear scientific communication.

Purpose of the Study:

• To propose a systematic nomenclature for common unconjugated and conjugated bile acids.
• To provide guidelines for naming newly discovered bile acids.
• To establish standardized terminology for bile acid derivatives and conjugates.

Main Methods:

• Tabulation of acceptable trivial names for bile acids.
• Development of guidelines for creating semi-systematic names from existing trivial names.
• Proposal of specific nomenclature for epimeric, unsaturated, and substituted bile acids.
• Recommendations for naming conjugated bile acids, including sulfates, glucuronides, and aminoacyl amidates.

Main Results:

• A comprehensive system for bile acid nomenclature is presented.
• Specific recommendations are made for replacing existing terms (e.g., alpha-hyocholic, beta-hyocholic).
• Guidelines facilitate the naming of novel and complex bile acid structures.
• Standardized abbreviations and terms for conjugates are proposed.

Conclusions:

• The proposed nomenclature system enhances clarity and consistency in bile acid research.
• Adoption of these guidelines will facilitate future discoveries and communication.
• The system moves away from species-based naming towards a systematic approach.
• This standardization is vital for the advancement of bile acid science.