Related Experiment Video
Updated: Aug 23, 2026

Quantification of Intracellular Growth Inside Macrophages is a Fast and Reliable Method for Assessing the Virulence of Leishmania Parasites
Published on: March 16, 2018
LD1 amplifications in Leishmania
1Departamento de Genética y Microbiología, Facultad de Medicina, Universidad de Murcia, Spain. msegovia@fcu.um.es
Abstract:
The genome of Leishmania is quite plastic. Chromosomal rearrangements and DNA amplifications are common events in all the species of the genus. Gene amplification occurs both as a mechanism of drug resistance and in the absence of drug pressure. The best known spontaneous amplification in Leishmania is the so-called LD1 family of amplicons. In the past few years there have been great advances in our knowledge of LD1 elements; here, Manuel Segovia and Ginés Ortiz review all the available data.
Related Concept Videos
Leishmaniasis
Antiprotozoal Agents

