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In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
Published on: July 27, 2010
Interleukin 12 and the regulation of CD4+ T-cell subset responses during murine Leishmaniasis
1Division of Geographic Medicine, Case Western Reserve University School of Medicine and the VA Medical Center, Cleveland, OH 44106, USA.
Parasitology Today (Personal Ed.)
|January 1, 1994
Abstract:
Interleukin 12 is unique among cytokines in that it is capable of protecting genetically susceptible mice against progressive infection with Leishmania major. Because of the probable causal relationships between CD4(+) T-cell differentiation, cytokine production and disease outcome, this cytokine may prove useful as a component of cytokine-bosed therapies and Thl-selective vaccines, as discussed here by Frederick Heinzel.
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