Related Experiment Video
Updated: Aug 23, 2026

2D and 3D Chromosome Painting in Malaria Mosquitoes
Published on: January 6, 2014
Organization of chromosomes in Plasmodium falciparum: a model for generating karyotypic diversity
M Lanzer1, D de Bruin, S P Wertheimer
1DeWitt Wallace Research Laboratory, Division of Molecular Biology, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10021, USA.
Abstract:
Chromosomes of the human malaria parasite, Plasmodium falciparum, are compartmentalized into conserved and polymorphic domains. The conserved domains are transcribed and localized within the central region o f a chromosome, whereas the polymorphic domains are transcriptionally silent and situated at chromosome ends. Unlike the central chromosomal domains, chromosome ends contain repetitive sequence elements. In this review, Michael Lonzer, Derik de Bruin, Samuel Wertheimer and Jeffrey Ravetch propose that the chromosome ends play a functional role in generating genetic diversity by promoting meiotic and mitotic recombination and chromosomal rearrangement events.
Related Concept Videos
Karyotyping
Polytene Chromosomes
Lampbrush Chromosomes
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Diversity of Protists II
Chromosome Structure
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Centrosome Duplication
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...

