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A computer program (DCN) for numerical convolution and deconvolution of pharmacokinetic functions.

J M Lanao1, M T Vicente, M L Sayalero

  • 1Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Spain.

Journal of Pharmacobio-Dynamics
|May 1, 1992
PubMed
Summary

A new microcomputer program, DCN, performs numerical convolution and deconvolution using polyexponential functions for pharmacokinetic analysis. This tool aids in understanding drug absorption, distribution, and release processes.

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Area of Science:

  • Pharmacokinetics
  • Computational Biology
  • Biotechnology

Background:

  • Pharmacokinetic analysis often utilizes polyexponential functions.
  • Numerical methods are crucial for complex pharmacokinetic modeling.
  • Existing tools may lack flexibility or accessibility for microcomputers.

Purpose of the Study:

  • To develop a user-friendly microcomputer program (DCN) for pharmacokinetic analysis.
  • To implement numerical convolution and deconvolution using polyexponential functions.
  • To provide a versatile tool for simulating and analyzing pharmacokinetic processes.

Main Methods:

  • The DCN program uses numerical integration (trapezoidal rule) for deconvolution.
  • It accepts user-defined coefficients and exponentials for polyexponential functions.

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  • The program is written in Microsoft GWBASIC for broad microcomputer compatibility.

    • Main Results:

    • The DCN program successfully performs numerical convolution and deconvolution.
    • It provides both numerical and graphical outputs for pharmacokinetic analysis.
    • Its efficacy was validated against established deconvolution algorithms.

    Conclusions:

    • The DCN program offers an accessible and effective solution for pharmacokinetic modeling on microcomputers.
    • It facilitates the analysis of drug absorption, distribution, and release.
    • The program's capabilities extend to simulating pharmacokinetic processes.