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Updated: Aug 23, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
[Pathogenesis and treatment of Wilson's disease]
Judit Nagy1, Zoltán Vincze, Anikó Folhoffer
1Semmelweis Egyetem Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet, Budapest, Hogyes E. u. 7-9.-1092.
Abstract:
Authors review the pathogenesis, symptoms and diagnosis of Wilson's disease. Wilson's disease or hepatolenticular degeneration is an autosomal recessive disorder. It is caused by defective hepatic excretion of copper. The disease is fatal without treatment. The prevention of severe permanent damage depends upon early recognition and diagnosis followed by appropriate lifelong anticopper treatment. The purpose of the therapy of Wilson's disease is to eliminate the copper by chelators (D-penicillamine, triethylene tetramine, ammonium tetrathiomolibdate) and to inhibit the absorption and accumulation of copper by zinc salts (zinc sulphate, zinc acetate, zinc gluconate).
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