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Whatever happened to cassette-dosing pharmacokinetics?
Prasarn Manitpisitkul1, Ronald E White
1Johnson & Johnson, Pharmaceutical Research & Development LLC, 920 US Route 202, Raritan, NJ, USA.
Drug Discovery Today
|July 29, 2004
Summary
Cassette dosing, a method for drug candidate screening, is controversial. Industry opinions are divided, with only half of companies using this pharmacokinetic assessment technique.
Area of Science:
- Pharmacology and Drug Development
- Biotechnology
- Pharmaceutical Sciences
Background:
- Cassette dosing involves administering a mixture of compounds to assess pharmacokinetics rapidly.
- This method presents both advantages and disadvantages, leading to debate regarding its application.
- Current industry practices for cassette dosing remain unclear.
Purpose of the Study:
- To investigate the current utilization and perceptions of cassette dosing in the pharmaceutical industry.
- To understand the extent to which cassette dosing is employed for in vivo pharmacokinetic screening.
Main Methods:
- A survey was conducted across multiple pharmaceutical companies.
- Data analysis focused on current practices and opinions regarding cassette dosing.
Main Results:
- Opinions on cassette dosing are significantly divided within the pharmaceutical industry.
- Approximately 50% of companies performing in vivo pharmacokinetic screening utilize cassette dosing.
Conclusions:
- The use of cassette dosing in drug discovery is not universally adopted.
- Further research may be needed to standardize or clarify the role of cassette dosing in pharmacokinetic assessments.