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Updated: Aug 23, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Synthesis and co-polymerization of an unsaturated 1,5-anhydro-D-fructose derivative
Olaf Deppe1, Anke Glümer, Shukun Yu
1Institute for Technical Chemistry, Department of Carbohydrate Technology, Technical University of Braunschweig, Langer Kamp 5, 38106 Braunschweig, Germany. o.deppe@tu-bs.de
Abstract:
An unsaturated derivative, 3,6-di-O-acetyl-1,5-anhydro-4-deoxy-D-glycero-hex-3-enopyranos-2-ulose (3), was obtained via regioselective elimination and acetylation of monohydrated 1,5-anhydro-D-fructose (1) in a single step reaction. High yield (80%) was achieved without any dimeric by-products. Its co-polymerization to saccharide polymers was investigated with different commercial vinyl co-monomers. Co-polymers were obtained and characterized.
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