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Synthesis and biological evaluation of caulibugulones A-E
Peter Wipf1, Beomjun Joo, Theresa Nguyen
1Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
Organic & Biomolecular Chemistry
|July 29, 2004
Abstract:
The marine bryozoan metabolites caulibugulone A-E were prepared from a readily available isoquinoline dione. These natural products were found to be potent and selective inhibitors of the dual specificity phosphatase Cdc25B.