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Related Experiment Videos

Rapid T2 estimation with phase-cycled variable nutation steady-state free precession.

Sean C L Deoni1, Heidi A Ward, Terry M Peters

  • 1Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada.

Magnetic Resonance in Medicine
|July 30, 2004
PubMed
Summary
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This study introduces a new method for Magnetic Resonance Imaging (MRI) that reduces artifacts in T2 relaxation mapping. The enhanced technique allows for faster, high-resolution brain imaging with improved accuracy.

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Medical Physics

Background:

  • Steady-state free precession (SSFP) imaging, specifically Double Echo in Steady State (DESS) with variable nutation (DESPOT2), enables rapid, high-resolution T2 relaxation mapping.
  • A significant limitation of DESPOT2 is the occurrence of T2 voids caused by off-resonance banding artifacts, which are exacerbated by long repetition times (TR), B0 inhomogeneities, and magnetic susceptibility differences.

Purpose of the Study:

  • To present a novel implementation of DESPOT2 that mitigates off-resonance banding artifacts.
  • To enable artifact reduction for improved spatial resolution and accuracy in T2 mapping.

Main Methods:

  • Incorporation of radiofrequency (RF) phase-cycling into the DESPOT2 sequence.
  • RF phase-cycling shifts the spatial location of banding artifacts.

Related Experiment Videos

  • Reconstruction of a single, artifact-reduced image from phase-cycled acquisitions.

    • Main Results:

    • Demonstration of the novel DESPOT2 implementation in vivo.
    • Acquisition of a 0.34 mm³ isotropic resolution T2 map of the brain.
    • Significant reduction in banding artifacts compared to conventional DESPOT2.

    Conclusions:

    • The novel RF phase-cycling approach effectively reduces artifacts in DESPOT2 T2 mapping.
    • This method allows for high-precision, high-accuracy, and high-resolution T2 mapping of the brain.
    • The technique overcomes previous spatial resolution constraints imposed by artifacts.