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Molecular characterization of low pathogenicity H7N3 avian influenza viruses isolated in Italy

L Di Trani1, B Bedini, P Cordioli

  • 1Department of Food and Animal Health, Istituto Supieriore di Sanità, Rome, 00161, Italy.

Avian Diseases
|July 31, 2004
PubMed

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Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...