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Related Experiment Videos

Aleukemic congenital leukemia cutis.

Antonio Torrelo1, Luis Madero, Imelda G Mediero

  • 1Department of Pediatric Dermatology, Hospital de Nino Jesús, Madrid, Spain. atorrelf@meditex.es

Pediatric Dermatology
|July 31, 2004
PubMed
Summary
This summary is machine-generated.

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A newborn girl presented with "blueberry muffin" lesions indicative of leukemia cutis. Despite persistent skin lesions, bone marrow infiltration was not detected, and she tragically died from pulmonary hypertension.

Area of Science:

  • Pediatric Oncology
  • Dermatology
  • Hematology

Background:

  • Leukemia cutis is a rare manifestation of leukemia, particularly in neonates.
  • The
  • blueberry muffin
  • sign is characteristic of extramedullary hematopoiesis or leukemic infiltration in infants.

Observation:

  • A newborn female infant presented with multiple, widespread, violaceous papules and nodules, consistent with the
  • blueberry muffin
  • rash.
  • Skin biopsy revealed histopathologic features of myelomonocytic leukemia cutis.
  • Repeated bone marrow aspirates (four) failed to demonstrate leukemic infiltration.

Findings:

  • The infant's leukemia cutis persisted despite the absence of detectable bone marrow involvement.

Related Experiment Videos

  • The patient developed severe primary pulmonary hypertension.
  • The infant succumbed to complications of pulmonary hypertension at 7 months of age.

    • Implications:

    • This case highlights the possibility of leukemia cutis in neonates without concurrent bone marrow infiltration.
    • It underscores the importance of considering cutaneous leukemia in the differential diagnosis of neonatal skin lesions.
    • The findings suggest that cutaneous leukemia can follow an independent clinical course from bone marrow involvement, impacting prognosis and management.