Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Embryonic stem cell therapy in experimental stroke: host-dependent malignant transformation].

Franciska Erdo1, Thorsten Trapp, Christian Bührle

  • 1Experimentelle Neurologie, Max-Planck Institut für neurologische Forschung, Köln, Németország. franciska.erdo@idri.hu

Orvosi Hetilap
|August 3, 2004
PubMed
Summary

Murine embryonic stem cell transplantation in rodent stroke models showed varied outcomes. While cells differentiated in rats, they formed teratocarcinomas in mice, raising safety concerns for human embryonic stem cell therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hybrid Nanofibers for Multimodal Accelerated Wound Healing.

Advanced healthcare materials·2026
Same author

In Vitro Functional and Structural Evaluation of Low-Complexity Artificial Human Epidermis for 3D Tissue Engineering.

Bioengineering (Basel, Switzerland)·2025
Same author

Progress in Topical and Transdermal Drug Delivery Research-Focus on Nanoformulations.

Pharmaceutics·2024
Same author

Mathematical modeling of transdermal delivery of topical drug formulations in a dynamic microfluidic diffusion chamber in health and disease.

PloS one·2024
Same author

Rodent models of dermatological disorders.

Italian journal of dermatology and venereology·2024
Same author

Models for barrier understanding in health and disease in lab-on-a-chips.

Tissue barriers·2023

Area of Science:

  • Stem cell biology
  • Neuroscience
  • Regenerative medicine

Context:

  • Embryonic stem cells (ESCs) show promise for treating neurodegenerative diseases like stroke.
  • Preclinical models are crucial for evaluating ESC safety and efficacy.
  • Rodent models are commonly used to study stroke and potential therapies.

Purpose:

  • To investigate the therapeutic potential and safety of murine ESCs in rodent stroke models.
  • To compare the outcomes of xenotransplantation and homologous transplantation of ESCs.
  • To assess ESC differentiation and tumor formation after brain ischemia.

Summary:

  • Murine ESCs were transplanted into rodent brains following focal ischemia.
  • In rats, ESCs migrated and differentiated into neurons near the ischemic injury (xenotransplantation).

Related Experiment Videos

  • In mice, homologous transplantation of the same ESCs resulted in teratocarcinoma formation, irrespective of predifferentiation.

    • Impact:

    • This study highlights significant safety concerns regarding ESC xenotransplantation and homologous transplantation in preclinical stroke models.
    • The findings question the direct translation of positive xenologous results to homologous settings.
    • Raises critical considerations for the safety evaluation of human ESCs in clinical trials for stroke.