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Endophthalmitis caused by Streptococcus pneumoniae.

John J Miller1, Ingrid U Scott, Harry W Flynn

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33101, USA.

American Journal of Ophthalmology
|August 4, 2004
PubMed
Summary

Endophthalmitis caused by Streptococcus pneumoniae, a serious eye infection, often leads to poor visual outcomes despite prompt antibiotic treatment. This study highlights the challenges in managing this condition and emphasizes the need for further research into effective strategies.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Endophthalmitis is a severe intraocular infection that can lead to vision loss.
  • Streptococcus pneumoniae is a common bacterial pathogen implicated in endophthalmitis.

Purpose of the Study:

  • To investigate the clinical characteristics, management approaches, antibiotic susceptibility patterns, and visual acuity outcomes in patients with endophthalmitis caused by Streptococcus pneumoniae.

Main Methods:

  • A retrospective, observational case series was conducted.
  • Patient records from Bascom Palmer Eye Institute (1989-2003) with culture-proven Streptococcus pneumoniae endophthalmitis were reviewed.
  • Data collected included clinical settings, treatment strategies, antibiotic sensitivities, and visual acuity outcomes.

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Main Results:

  • Twenty-seven cases of Streptococcus pneumoniae endophthalmitis were analyzed.
  • Common clinical settings included postoperative, corneal ulcer, and bleb-associated infections.
  • While most isolates were sensitive to vancomycin and fluoroquinolones, final visual acuity was poor in a significant proportion of cases (37% no light perception).

Conclusions:

  • Endophthalmitis due to Streptococcus pneumoniae is associated with a poor visual prognosis, even with timely and appropriate antibiotic therapy.
  • The findings underscore the severity of this infection and the limitations of current treatment paradigms.