Divergent responses to saccharin vs. sucrose availability after stress in rats

Rats were exposed to 100 5-s inescapable, unpredictable shocks then had access to water and saccharin or sucrose solution for 5-6 days. Shock reduced daily drinking during saccharin tests (Experiments 1, 2B, 4) and increased daily drinking during sucrose tests (Experiment 2B). In addition, shock reduced body weight when saccharin, but not when sucrose, was available (Experiments 1, 2B). The specificity of the reductions to saccharin tests (Experiments 2B, 4), equal intake of flavors shortly after stress (Experiments 2B to 4), and failure of saccharin-naive and saccharin-familiar groups to differ (Experiment 3) argue against a neophobia interpretation. Normal or above-normal drinking during sucrose (Experiment 2B) or water-only (Experiment 4) tests indicate an absence of general hedonic, motoric, or hydrational deficits. Qualitative differences in the tastes of saccharin and sucrose may underlie their disparate effects on drinking after shock. Whatever the mechanisms, the present results show that even a severe stressor can decrease or increase ingestion, depending on the flavors available.