Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyamines and cancer: minireview article.

U Bachrach1

  • 1Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel. bachr@md.huji.ac.il

Amino Acids
|August 4, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antiviral activity of oxidized polyamines.

Amino acids·2007
Same author

The specific anti-cancer activity of green tea (-)-epigallocatechin-3-gallate (EGCG).

Amino acids·2002
Same author

Cancer therapy and prevention by green tea: role of ornithine decarboxylase.

Amino acids·2002
Same author

Polyamines: new cues in cellular signal transduction.

News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society·2001
Same author

A luminescence-based test for determining ornithine decarboxylase activity.

Analytical biochemistry·2000
Same author

Effects of testosterone and 17, beta-estradiol on the polyamine metabolism in cultivated normal rat kidney epithelial cells.

Amino acids·2000

Polyamines like spermine and spermidine are linked to cancer. Measuring these compounds and inhibiting their synthesis shows promise for cancer detection and treatment strategies.

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Naturally occurring polyamines (spermine, spermidine, putrescine) are vital for cellular growth and differentiation.
  • Elevated polyamine levels are observed in cancerous tissues and body fluids, indicating a role in cancer progression.
  • Polyamines and their synthesis pathways are increasingly recognized for their diagnostic and therapeutic potential in oncology.

Purpose of the Study:

  • To explore the role of polyamines in cancer.
  • To review the diagnostic and therapeutic applications of polyamines in cancer management.
  • To highlight novel approaches utilizing polyamine metabolism for cancer treatment.

Main Methods:

  • Review of existing literature on polyamine metabolism and cancer.

Related Experiment Videos

  • Analysis of polyamine assays in body fluids for cancer detection and therapy monitoring.
  • Evaluation of ornithine decarboxylase as a proliferation marker and its use in chemosensitivity testing.

    • Main Results:

    • Polyamines are significantly elevated in cancer patients.
    • Urinary and blood polyamine levels can serve as biomarkers for cancer detection and treatment efficacy.
    • Inhibition of polyamine synthesis shows potential for cancer prevention and therapy.
    • A new in vitro chemosensitivity assay based on ornithine decarboxylase activity has been developed.

    Conclusions:

    • Polyamines are crucial players in cancer biology with significant diagnostic and therapeutic implications.
    • Targeting polyamine synthesis pathways offers a promising strategy for cancer treatment.
    • Further research into polyamines and their derivatives could enhance cancer diagnosis and therapy.