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Related Experiment Videos

Biogenic amines and apoptosis: minireview article.

A Toninello1, M Salvi, P Pietrangeli

  • 1Department of Biological Chemistry and CNR Center for the Study of Biomembranes, University of Padua, Padua, Italy.

Amino Acids
|August 4, 2004
PubMed
Summary
This summary is machine-generated.

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High concentrations of biogenic amines (BA) protect against apoptosis by scavenging reactive oxygen species (ROS). However, amine oxidases (AO) can trigger apoptosis by producing ROS and aldehydes from BA.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Programmed cell death (apoptosis) is a complex process influenced by intracellular factors.
  • Biogenic amines (BA) play a significant role in regulating apoptosis.
  • Mitochondrial damage, induced by hydrogen peroxide and aldehydes from BA oxidation, is a key event in apoptosis.

Purpose of the Study:

  • To investigate the dual role of biogenic amines (BA) in apoptosis.
  • To explore the mechanisms by which BA influence apoptosis triggering and protection.
  • To examine the effects of monoamine oxidase (MAO) inhibitors on apoptosis.

Main Methods:

  • Analysis of the relationship between intracellular BA concentration and apoptosis.
  • Investigation of the role of amine oxidases (AO) in BA-mediated mitochondrial damage.

Related Experiment Videos

  • Evaluation of the protective effects of high BA concentrations and MAO inhibitors on mitochondria.

    • Main Results:

    • High BA concentrations protect against apoptosis, potentially via ROS scavenging and membrane pore interaction.
    • Amine oxidases (AO) mediate the production of harmful hydrogen peroxide and aldehydes from BA, leading to mitochondrial damage.
    • Monoamine oxidase (MAO) inhibitors, such as propargylamines, preserve mitochondrial integrity by inhibiting MAO and regulating membrane pores.

    Conclusions:

    • Apoptosis is protected by high concentrations of BA and/or other cations.
    • Apoptosis is favored by reactive oxygen species (ROS) produced by amine oxidases (AO) or other mechanisms.
    • MAO inhibitors offer mitochondrial protection, similar to BA, by reducing ROS production and modulating membrane pores.