Complications of orthotopic liver transplantation: imaging findings

Orthotopic liver transplantation has become the major treatment for end-stage chronic liver disease and for severe acute liver failure. Despite the improvement in survival due to advances in organ preservation, improved immunosuppressive therapy agents, and refinement of surgical techniques, there are significant complications after liver transplantation. These complications mainly include biliary strictures, stones, and leakage; arterial and venous stenoses and thromboses; lymphoproliferative disorders; recurrent tumors; hepatitis virus C infection; liver abscesses; right adrenal gland hemorrhage; fluid collections; and hematomas. The diagnosis of acute rejection, one of the most serious complications after liver transplantation, is established with graft biopsy and histologic study. The role of imaging methods consists of excluding the other complications, which can have clinical signs and symptoms similar to those of acute rejection. This pictorial essay describes imaging findings of the various complications after liver transplantation and focuses on their radiologic diagnosis. Knowledge and early recognition of these complications with the most suitable imaging modality are crucial for graft and patient survival.