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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jul 11, 2026

A Modified Method for Heterotopic Mouse Heart Transplantion
11:29

A Modified Method for Heterotopic Mouse Heart Transplantion

Published on: June 24, 2014

[Personal experience with heart transplantation].

J Hejnal1, I Málek, P Firt

  • 1Institut klinické a experimentální medicíny, Praha-Krc.

Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti
|July 1, 1992
PubMed
Summary

This study analyzed 72 heart transplants (1984-1991), finding cardiac failure and renal failure as primary early complications. Long-term survivors faced sudden cardiac death, often linked to coronary artery disease.

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Last Updated: Jul 11, 2026

A Modified Method for Heterotopic Mouse Heart Transplantion
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Murine Heterotopic Heart Transplant Technique
10:27

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Published on: July 9, 2014

An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats
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An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats

Published on: May 8, 2020

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Immunology

Context:

  • Irreversible cardiac failure necessitates advanced treatment options.
  • Orthotopic heart transplantation emerged as a viable solution during the 1984-1991 period.
  • The Institute of Clinical and Experimental Medicine conducted a significant series of cardiac transplantations.

Purpose:

  • To evaluate the outcomes of orthotopic heart transplantation in patients with end-stage cardiac failure.
  • To identify early and late complications following heart transplantation.
  • To assess long-term survival rates and causes of mortality after cardiac transplantation.

Summary:

  • 72 orthotopic heart transplantations were performed between 1984-1991 in patients with irreversible cardiac failure.
  • Common indications included ischemic heart disease (IHD), cardiomyopathy, rheumatic heart disease (RHD), and cardiac tumors.
  • Immunosuppression utilized Azathioprine, corticosteroids, and Cyclosporine A.
  • Early mortality (within one month) was 19 patients, primarily due to cardiac failure; renal failure was the most frequent postoperative complication.
  • Long-term follow-up of 50 patients revealed a maximum survival of 8 years and 2 months, with sudden death (likely due to coronary artery disease) being the leading cause of late mortality.

Impact:

  • Provides insights into the early challenges and long-term risks associated with heart transplantation.
  • Highlights the importance of managing cardiac failure and preventing coronary artery disease progression post-transplant.
  • Informs clinical practice regarding immunosuppression protocols and patient monitoring strategies.