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Genetic Markers at ANRIL, FTO and 2q36.3 Locus in Czech Patients Undergoing Coronary Artery Bypass Graft Surgery
P Kacer1,2, J Pirk2, V Lanska3
1Department of Cardiac Surgery, Královské Vinohrady University Hospital in Prague, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Insights
Genetic markers for cardiovascular disease (CVD) were analyzed in patients undergoing coronary artery bypass graft (CABG) surgery. The ANRIL gene variant was more common in CABG patients, suggesting a link to CVD risk.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Epidemiology
Background:
- Coronary artery bypass graft (CABG) surgery is a prevalent procedure globally.
- Understanding genetic predispositions to cardiovascular disease (CVD) is crucial for risk assessment.
- Previous studies have identified several genetic markers associated with CVD.
Purpose of the Study:
- To compare the frequencies of three major CVD-associated genetic markers (ANRIL, FTO, and 2q36.3 locus) between CABG patients and controls.
- To investigate the association of these genetic variants with CVD risk in a Czech population.
Main Methods:
- Genotype frequencies of ANRIL (rs10757274 polymorphism), FTO, and 2q36.3 locus were analyzed.
- Comparison was made between 753 CABG patients and 2,559 controls from the Czech post-MONICA study.
- Statistical analysis included odds ratios (OR) with 95% confidence intervals (CI) and P-values.
Main Results:
- Subjects with the major A allele in the ANRIL rs10757274 polymorphism were significantly more prevalent in CABG patients (81.7%) compared to controls (72.7%) (OR 1.67; P < 0.0001).
- No significant association was found for variants within the FTO gene (OR 0.87; P = 0.24) or the 2q36.3 locus (OR 1.16; P = 0.08) with CVD in this cohort.
- No associations were observed between these genetic variants and anthropometric, biochemical, or clinical characteristics in the patient group.
Conclusions:
- The ANRIL gene variant rs10757274 is significantly associated with increased prevalence in patients who have undergone CABG surgery.
- FTO gene variants and the 2q36.3 locus were not found to be significantly associated with CVD in the studied Czech population.
- Patients undergoing CABG surgery are more likely to be carriers of certain CVD-associated alleles, particularly within the ANRIL gene.
Abstract:
Coronary artery bypass graft (CABG) surgery is one of the most commonly performed operations worldwide. We compared genotype frequencies of three major cardiovascular disease (CVD)-associated genetic markers (ANRIL, FTO and 2q36.3 locus) between 753 patients who underwent CABG at the Institute for Clinical and Experimental Medicine (Prague, Czech Republic) and 2,559 controls from the Czech post-MONICA study. Subjects with at least one major A allele in the rs10757274 polymorphism (ANRIL) were more prevalent in patients after CABG than in the controls (81.7 % vs 72.7 %; OR [95 % CI] 1.67 [1.35-2.05]; P < 0.0001). In contrast, variants within the FTO gene (OR 0.87; 95 % CI, 0.70-1. 09 in a TT vs. GG comparison, P = 0.24) and 2q36.3 locus (OR 1.16; 95% CI, 0.98-1.37 in a +A vs. CC comparison, P = 0.08) were not significantly associated with CVD in our study. Variants were not associated with anthropometric, biochemical, or clinical characteristics within the patient group. Our study suggests that patients with CABG are more commonly carriers of some but not all CVD-associated alleles.
