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Tremor analysis in two normal cohorts.

J Raethjen1, M Lauk, B Köster

  • 1Department of Neurology, University of Kiel, Niemannsweg 147, 24105 Kiel, Germany.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|August 6, 2004
PubMed
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Comparing tremor analysis methods in two large normal cohorts revealed that while tremor amplitude and frequency varied, reduced frequency under load and absent rhythmic EMG were reproducible findings. This suggests a need for lab-specific normative data for accurate diagnostic differentiation.

Area of Science:

  • Clinical Neurophysiology
  • Movement Disorders
  • Biomedical Engineering

Background:

  • Quantitative tremor analysis is crucial for diagnosing movement disorders.
  • Standardization of tremor measurement methods across different centers is lacking.
  • Variability in recording conditions can impact tremor analysis results.

Purpose of the Study:

  • To compare quantitative tremor analyses between two independent normal cohorts using similar methods.
  • To identify robust tremor measures for diagnostic use versus those requiring lab-specific normalization.
  • To establish a framework for standardized tremor analyses in clinical neurophysiology.

Main Methods:

  • Hand accelerometry and surface electromyography (EMG) were recorded from forearm muscles in 117 and 67 healthy volunteers across two German movement disorder centers.

Related Experiment Videos

  • Recordings were performed under postural conditions with and without 500g and 1000g weight loading.
  • Tremor amplitude (total power) and frequency were analyzed.

    • Main Results:

    • Tremor amplitude and frequency ranges were similar but showed significant differences between centers.
    • A significant reduction in tremor frequency (>1 Hz) was observed under 1000g weight load in both cohorts.
    • Approximately 85-90% of recordings showed a lack of rhythmic EMG activity at the tremor frequency, a reproducible finding.

    Conclusions:

    • Tremor frequency and total power are sensitive to subtle differences in recording conditions, necessitating lab-specific normative data.
    • At least 25 normal subjects are estimated to be required for establishing reliable normative values.
    • The load-induced frequency reduction and absent tremor-related EMG activity are robust indicators for differentiating physiological from low-amplitude pathological tremor.