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Resistance training effectiveness in patients with Charcot-Marie-Tooth disease: recommendations for exercise
Robert D Chetlin1, Laurie Gutmann, Mark Tarnopolsky
1Department of Human Performance & Applied Exercise Science, School of Medicine, West Virginia University, Morgantown, WV 26506-9139, USA. rchetlin@hsc.wvu.edu
Objectives:
To determine the effects of a 12-week, home-based resistance exercise program on strength, body composition, and activities of daily living (ADLs) in men and women with Charcot-Marie-Tooth (CMT) disease and to design an ADL-based resistance exercise prescription template.
Design:
Double-blind, placebo-controlled study.
Setting:
Testing in a university setting; exercise in patients' homes.
Participants:
Twenty CMT patients who volunteered.
Intervention:
Subjects progressively strength trained at home 3 d/wk for 12 weeks.
Main Outcome Measures:
Timed ADLs, isometric strength, and body composition.
Results:
Absolute strength was greater in men with CMT in only 4 of 10 baseline measures (P<.05), but not when strength was normalized by lean mass. Training compliance was 87% with no gender differences. At baseline, women had 80% of normal strength in 4 of 10 measures, whereas men did not achieve 80% of normal strength in any measure. After training, women had 80% of normal strength in 8 of 10 measures, whereas men only had 80% of normal strength in 1. Training volumes and strength change scores showed no gender differences. ADLs improved after training with no gender differences (P<.05). An exercise prescription template was developed by using chair-rise time to estimate starting weights for lower body and supine rise for upper body.
Conclusions:
Resistance training improved strength and ADLs equally in men and women. We designed an exercise prescription recommendation, based on ADL performance.
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