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Potential complications of segmental hemangiomas of infancy

Denise W Metry1

  • 1Departments of Dermatology and Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030-2399, USA. dmetry@bcm.tmc.edu

Seminars in Cutaneous Medicine and Surgery
|August 7, 2004
PubMed

Insights

Segmental hemangiomas, particularly those associated with PHACE syndrome, can cause serious complications. Early recognition and work-up are crucial for managing these infants and preventing adverse outcomes.

Area of Science:

  • Pediatric Dermatology
  • Medical Genetics
  • Developmental Biology

Background:

  • Infantile hemangiomas typically resolve benignly, but some present serious complications.
  • Segmental morphology hemangiomas are linked to significant health risks.
  • PHACE syndrome is a recognized association with specific hemangioma types.

Purpose of the Study:

  • To review PHACE syndrome manifestations and pathogenesis.
  • To discuss the work-up and management of PHACE syndrome.
  • To explore other complications of segmental hemangiomas.

Main Methods:

  • Literature review of PHACE syndrome and segmental hemangiomas.
  • Analysis of clinical presentations and associated anomalies.
  • Discussion of diagnostic and therapeutic strategies.

Main Results:

  • PHACE syndrome involves posterior fossa brain malformations, segmental cervicofacial hemangiomas, arterial anomalies, cardiac defects, and eye anomalies.
  • PHACE(S) includes ventral developmental defects like sternal clefting.
  • Segmental hemangiomas can also lead to ulceration, visceral, and lumbosacral anomalies.

Conclusions:

  • Segmental hemangiomas are markers for serious underlying conditions, notably PHACE syndrome.
  • Comprehensive evaluation is essential for infants with segmental hemangiomas.
  • Further research into pathogenesis and management is warranted.

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