Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[GLUT8- and AMPK-Dependent Autophagy Signaling in the Mechanism of the Neuroprotective Action of Trehalose].

Molekuliarnaia biologiia·2026
Same author

Dechorionation at an Early Stage of Embryogenesis Modifies the Behavior and Biogenic Amines in the Brain of Adult Zebrafish (Danio rerio).

Bulletin of experimental biology and medicine·2026
Same author

[The FOUR scale in assessing patients with acute cerebral insufficiency].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko·2026
Same author

Metabolic effects of trehalose in mice of the C57BL/6 strain with obesity induced by a high carbohydrate-fat diet.

Vavilovskii zhurnal genetiki i selektsii·2025
Same author

"Homeostatic" Cytokines Enhance the Expression of PD-1, Tim-3, and Their Ligands on Myeloid Cells.

Bulletin of experimental biology and medicine·2025
Same author

Arginase-1 and Mer Tyrosine Kinase Expression in Monocyte Populations in Patients with Axial Spondyloarthritis.

Bulletin of experimental biology and medicine·2025

Related Experiment Video

Updated: Jul 18, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

[Effect of experimental elevation and decrease of thyroxine level on catalepsy in rats].

A V Kulikov, M A Tikhonova, E I Lebedeva

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |August 7, 2004
    PubMed
    Summary

    Thyroid dysfunction impacts rat behavior. Both low and high thyroxine levels increased catalepsy, but affected different forms of freezing responses.

    More Related Videos

    In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
    04:14

    In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

    Published on: October 6, 2023

    A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function
    04:05

    A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function

    Published on: October 6, 2023

    Related Experiment Videos

    Last Updated: Jul 18, 2026

    Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
    09:07

    Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

    Published on: August 15, 2017

    In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
    04:14

    In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

    Published on: October 6, 2023

    A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function
    04:05

    A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function

    Published on: October 6, 2023

    Area of Science:

    • Neuroendocrinology
    • Behavioral Neuroscience

    Context:

    • Thyroid hormones play a crucial role in regulating physiological and psychological functions.
    • Thyroid dysfunction is frequently linked to various mental disorders, including depression and anxiety.

    Purpose:

    • To investigate the impact of experimentally altered thyroxine levels on distinct types of catalepsy in male Wistar rats.
    • To differentiate the effects of hypothyroidism and hyperthyroidism on spontaneous and pinch-induced freezing behaviors.

    Summary:

    • Chronic administration of propylthiouracil (a thyroxine synthesis inhibitor) reduced plasma thyroxine, significantly increasing spontaneous catalepsy but not affecting pinch-induced catalepsy.
    • Conversely, chronic thyroxine treatment did not alter spontaneous catalepsy but significantly enhanced pinch-induced catalepsy.
    • These findings indicate that both thyroid hormone deficiency and excess can induce catalepsy, selectively affecting different behavioral responses.

    Impact:

    • Provides novel insights into the complex relationship between thyroid hormone levels and specific behavioral phenotypes.
    • Highlights the differential effects of hypo- and hyperthyroidism on motor control and behavioral inhibition.
    • Suggests potential mechanisms underlying the association between thyroid dysfunction and psychiatric conditions characterized by altered motor activity.