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Updated: Aug 23, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Chk1 activation and the nuclear/cytoplasmic ratio
1Ben May Institute for Cancer Research, Committee on Cancer Biology, University of Chicago, 924 East 57th Street, IL 60637 USA.
Abstract:
ATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of Developmental Cell, Conn et al. shed a novel light on the molecular mechanism of Chk1 activation and raise the possibility of a developmental checkpoint that regulates Chk1 in response to the nuclear/cytoplasmic ratio.
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