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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

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Intrafamilial spread of the same clarithromycin-resistant Helicobacter pylori infection confirmed by molecular

Ikue Taneike1, Keibun Suzuki, Saori Nakagawa

  • 1Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibanchou, Asahimachidori, Niigata, Japan. tatsuoy@med.niigata-u.ac.jp

Journal of Clinical Microbiology
|August 7, 2004
PubMed

Insights

Clarithromycin-resistant Helicobacter pylori (CRHP) is increasing globally, particularly in children. A mother and child shared an identical CRHP strain, indicating intrafamilial transmission may be a growing concern.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Clarithromycin-resistant Helicobacter pylori (CRHP) is a growing global health concern.
  • Pediatric infections with CRHP are increasingly reported worldwide.
  • Helicobacter pylori eradication therapy often relies on clarithromycin.

Observation:

  • A case study involving a mother and child infected with CRHP was investigated.
  • DNA analysis was performed on isolates from both family members.
  • The study aimed to understand the transmission dynamics of CRHP within a family unit.

Findings:

  • DNA analysis confirmed that the CRHP isolates from the mother and daughter were indistinguishable.
  • This genetic identity strongly suggests the transmission of a single CRHP strain between the mother and child.
  • The findings highlight the potential for intrafamilial spread of resistant H. pylori strains.

Implications:

  • Intrafamilial transmission represents a significant route for the spread of CRHP.
  • Understanding familial transmission is crucial for developing effective prevention and control strategies.
  • This case underscores the need for vigilance regarding antibiotic resistance in pediatric populations.

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